Thursday, April 21, 2011

Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl or Vinyl Chlorides to α-Ketoamides Through CCl Bond Activation

Nickeleophilic addition! The first example of a nickel-catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C[BOND]Cl bond activation is reported, which takes place under mild reaction conditions (see scheme).
DOI: 10.1002/chem.201100256

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