Palladium-Catalyzed C–H Perfluoroalkylation of Arenes

A new Pd-catalyzed reaction for the coupling between perfluoroalkyl iodides (R_FI) and simple aromatic substrates is described. The perfluoroalkylated arene products are obtained in good to excellent yields in the presence of a phosphine-ligated Pd catalyst and Cs₂CO₃ as a base. The development, optimization, scope, and preliminary mechanistic studies of these transformations are reported.

http://pubs.acs.org/doi/abs/10.1021/ol200628n