Removable Directing Groups in Organic Synthesis and Catalysis

Abstract

Directing groups have been widely used in recent years to achieve control over all aspects of reaction selectivity in a wide range of transformations involving transition-metal catalysis and organometallic reagents. In cases when the existing functional group within a substrate is unsuited to achieve efficient intramolecular delivery of a reagent or catalyst, the specific introduction of an appropriately designed removable reagent-directing group can be a solution to this problem. In this Review we give an overview of the state of the art in this area, including the stoichiometric and catalytic use of directing groups.

1. Dr. Géraldine Rousseau, 
2. Prof. Dr. Bernhard Breit, Angew. Chem. Int. Ed, 2011

1. DOI: 10.1002/anie.201006139