Bond activation in action: Unprecedented ruthenium-catalyzed oxidative annulations of alkynes through cleavage of C![[BOND]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_srR-RyKJoWTCxozKPo_3czSgR1zuincOisipZO08eN8XaPpJYm3AvqC89PZHg41QwU6xtVC3ypVwWg6akAPT0zcYpyls0IWKSaaIrIY4xTca8FCQ8qPvmbzDzLFmlHLdryzd_WNP_poL-fgg=s0-d)
H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
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