Bond activation in action: Unprecedented ruthenium-catalyzed oxidative annulations of alkynes through cleavage of C![[BOND]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vEr7I13alncQIzsig9jKJJ7g6Dz9hWr0PQI0almwmjq8QRQmV-8i6nDOd9ocwlC7F1fPZzx0GQuG3xrTeyblqPUefP4TX-2Fu3H0RAJBdkYLxYRjBwunpK6YEMkHSLPEof3_hbEYTC3a5GUQ=s0-d)
H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
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