Cobalt-Catalyzed Chemoselective Insertion of Alkene into the Ortho C−H Bond of Benzamide - Journal of the American Chemical Society (ACS Publications)

Insertion of 1-alkene, 2-alkene, and styrene into the ortho C−H bond of benzamide in the presence of an inexpensive cobalt catalyst, DMPU as a crucial ligand, and cyclohexylmagnesium chloride proceeds smoothly at 25 °C to selectively give the ortho-alkylated product. Notable features of this reaction include the structural variety of the alkene and the amide substrate and the tolerance of functional groups such as halide, olefin, ester, and amide groups.