Copper-Catalyzed Trifluoromethylation of Unactivated Olefins - Parsons - 2011 - Angewandte Chemie International Edition - Wiley Online Library

Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.

1. Prof. Dr. Stephen L. Buchwald, 2011, 

DOI: 10.1002/anie.201104053