Tuesday, August 2, 2011

Rhodium-Catalyzed Oxidative ortho-Acylation of Benzamides with Aldehydes: Direct Functionalization of the sp2 C–H Bond

A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp2 C–H bond cleavage is described. In the presence of [Cp*RhCl2]2, AgSbF6, and silver carbonate as an oxidant, N,N-diethyl benzamides can be effectively carbonylated to yield ortho-acyl benzamides.


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