Synthesis of Quinolines via Rh(III)-Catalyzed Oxidative Annulation of Pyridines

Selective synthesis of quinolines has been achieved via oxidative annulation of functionalized pyridines with two alkyne molecules under Rh(III)-catalyzed cascade C–H activation of pyridines using Cu(OAc)₂ as an oxidant. The selectivity of this reaction is oxidant-dependent, particularly on the anion of the oxidant.


DOI: 10.1021/jo201266u