Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

Transition-metal-catalyzed C–H bond arylation has recently emerged as a powerful tool for the functionalization of organic molecules that may complement or even replace traditional catalytic cross-couplings. While many efforts have focused on the arylation of arenes and heteroarenes in the past two decades, less studies have been devoted to the arylation of nonacidic C–H bonds of alkyl groups. This tutorial review highlights recent work in this active area.