Copper-Mediated C–H Activation of 1,3,4-Oxadiazoles with 1,1-Dibromo-1-alkenes Using PEG-400 as a Solvent Medium: Distinct Approach for the Alkynylation of 1,3,4-Oxadiazoles

The direct C–H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73–86 %) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly.


DOI: 10.1002/ejoc.201101542