Wednesday, March 9, 2011

Base-Mediated Intermolecular sp2 C−H Bond Arylation via Benzyne Intermediates

Abstract:

A transition-metal-free method for arylation of heterocycle and arene carbon−hydrogen bonds by aryl chlorides and fluorides has been developed. The reactions proceed via aryne intermediates and are highly regioselective with respect to the C−H bond coupling component.

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