Rh(NHC)-Catalyzed Direct and Selective Arylation of Quinolines at the 8-Position

Abstract:

A new catalytic protocol for the regioselective direct arylation of quinoline derivatives at the 8-position has been developed. The reaction is catalyzed by a Rh(NHC) system, and the choice of the NHC ligand was most important for achieving high reactivity and selectivity.

http://pubs.acs.org/doi/abs/10.1021/ja111670s