Palladium-Catalyzed ortho-Acylation of Acetanilides with Aldehydes through Direct C[BOND]H Bond Activation

Easy access too-acyl acetanilides: A new Pd-catalyzed ortho-acylation of acetanilides with both aromatic and aliphatic aldehydes has been developed based on a CH activation process. In the presence of tert-butyl hydroperoxide (TBHP) as the ideal oxidant, this reaction provides an efficient access to ortho-acyl acetanilides in good yields (see scheme).


doi/10.1002/chem.201101192