Palladium-Catalyzed Oxidative sp2 C−H Bond Acylation with Alcohols

An efficient method was developed for the direct acylation of arene sp² C−H bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.


Org. Lett., 2011, 13 (7), pp 1614–1617