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Nature Chemistry

Thursday, September 8, 2011

Copper-Mediated Cyanation of Aryl Halide with the Combined Cyanide Source

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A simple copper-mediated cyanation of aryl halide with the combination of ammonium bicarbonate and N,N-dimethylformamide as a cyanide source is achieved, providing nitriles in moderate to good yields. This new approach represents an exceedingly practical and safe method for the synthesis of aryl nitriles.

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