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Saturday, October 1, 2011

Rhodium(III)-Catalyzed Oxidative Coupling of 5-Aryl-1H-pyrazoles with Alkynes and Acrylates


Abstract

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[RhCp*Cl2]2-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates has been achieved using Cu(OAc)2 as an oxidant. Coupling with alkynes afforded six-membered azacycles as a result of C–C and C–N coupling. Coupling with acrylates followed a process of diolefination and a subsequent aza-Michael cyclization.

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