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Nature Chemistry

Wednesday, January 25, 2012

A Highly Efficient Gold-Catalyzed Oxidative C[BOND]C Coupling from C[BOND]H Bonds Using Air as Oxidant


A breath of fresh air: The title reaction has been developed for the coupling of amines with nitroalkanes and different unmodified ketones using air as the sole oxidant under mild reaction conditions. The safe, convenient, and environmentally benign process, as well as the low catalyst loading, short reaction time, and good yields make this protocol very practical (see scheme).

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