Palladium-Catalyzed Amidation by Chemoselective C(sp3)[BOND]H Activation: Concise Route to Oxindoles Using a Carbamoyl Chloride Precursor

Quite select: A new strategy was developed for the synthesis of various oxindoles from carbamoyl chlorides. Under the optimum reaction conditions, with Ad2PBu as a ligand, tBuCONHOH as an additive, and a CO atmosphere, selective C(sp3)H activation proceeded in the presence of a C(sp2)H bond. Ad=adamantyl.