Tuesday, February 7, 2012

Palladium-Catalyzed Intermolecular C(sp3)[BOND]H Amidation



Dual capacity: A new palladium-catalyzed intermolecular sequence consisting of the CH activation and amidation of methyl groups relies on N-fluorobis(phenylsulfonyl)imide (NFSI) as both the oxidant and the nitrogen source. The reaction provides the corresponding arylamines as bissulfonimides along with HF as the only by-product. Both experimental and computational results suggest the involvement of a monomeric palladium(IV) intermediate.

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