A palladium-/copper-catalyzed intermolecular C–H amination reaction of indoles has been developed. This reaction proceeds in good to excellent yields to produce a variety of 2-amino-substituted indoles and exhibits excellent regioselectivity at room temperature. Furthermore, chloroamination of indoles provides a simple method for the construction of C–N and C–Cl bonds in one step.
Org Lett 2011.
No comments:
Post a Comment