Bond activation in action: Unprecedented ruthenium-catalyzed oxidative annulations of alkynes through cleavage of C![[BOND]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uo5oz8ujTF8E0RBFj9xxt1uG0BrizNhlpaItuyin8vBXGPi_E3TazjHDb6lsJiXebIGb1OfOvcQsgCjRL4VOop7XwnAz3rGkFmxiuh8cHSx4MqsnNv6GmxP-Mu09fNtzuB3CfUVP0qW4I--w=s0-d)
H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
H bonds set the stage for an efficient 1(2H)-isoquinolone synthesis with ample scope (see scheme; tAm=tert-amyl). Mechanistic studies provided strong evidence for a rate-limiting CH bond metalation through carboxylate assistance.
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