Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the C![[BOND]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vhb943WY3nexORGseebnPqAh8DEuCcBhKtGYtru6V2ePS12pr5CHRh4TYh7F2vQO6mmn6vslC9p_79Dcik8T4eOBFQQ5pbwKtHqtX7TZCe4VMxttXVbCgr6eT_zZlfDb5fojgRnPHcuozBrw=s0-d)
H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of 1 equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2alone.
H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of 1 equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2alone.
M.Sanford et al. DOI: 10.1002/anie.201103327
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