Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the C![[BOND]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uNNzKL4x73XovxQNMWGOcRdCsOMNXmAXLA1aatONvdR9ADkqvSqd7DxqRJvVRRjd76kF8FlFipmizwRCycxCv0ivNqk1YxKNSlY300pVIiIejXGAzoBWgVdZkOQ41yavtH6kr0xGVq-j3KJA=s0-d)
H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of 1 equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2alone.
H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of 1 equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2alone.
M.Sanford et al. DOI: 10.1002/anie.201103327
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