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Friday, June 24, 2011

Copper-Catalyzed Arylation of Arylboronic Acids with Aldehydes


Abstract

A novel copper-catalyzed arylation of arylboronic acids with aldehydes under oxygen atmosphere was achieved in the presence of Cu(OTf)2 and Xantphos, affording diaryl ketone derivatives in moderate to good yields. The efficiency of this reaction was demonstrated by the compatibility with fluoro, bromo, chloro, nitro, ­methylsulfonyl, and trifluoromethyl groups.

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