Ruthenium-NHC Catalyzed α-Alkylation of Methylene Ketones Provides Branched Products through Borrowing Hydrogen Strategy

DOI: 10.1021/acscatal.6b01351

One-pot synthesis of carbazoles from cyclohexanones and arylhydrazine hydrochlorides under metal-free conditions

Copper-catalyzed synthesis of benzocarbazoles via α-C-arylation of ketones

Chiral Aryl–Copper(III) Electrophiles: New Opportunities in Catalytic Enantioselective Arylations and Domino Processes - Rousseaux - 2012 - Angewandte Chemie International Edition - Wiley Online Library

Copper-Catalyzed Arylation of Arylboronic Acids with Aldehydes

Abstract

A novel copper-catalyzed arylation of arylboronic acids with aldehydes under oxygen atmosphere was achieved in the presence of Cu(OTf)₂ and Xantphos, affording diaryl ketone derivatives in moderate to good yields. The efficiency of this reaction was demonstrated by the compatibility with fluoro, bromo, chloro, nitro, ­methylsulfonyl, and trifluoromethyl groups.

Synlett 2011(11): 1626-1630

Regioselective Synthesis of Indenols by Rhodium-Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes

Ketones and alkynes join together: The catalytic title reaction proceeds rapidly at 120 °C and requires only 1 hour for completion (see scheme). The reaction mechanism likely involves chelation-assisted ortho CH activation, insertion of the alkyne moiety, carbocyclization, and protonation. Cp*=pentamethylcyclopentadienyl.

DOI: 10.1002/anie.201100229

Synthesis of Phenanthrone Derivatives from sec-Alkyl Aryl Ketones and Aryl Halides via a Palladium-Catalyzed Dual C−H Bond Activation and Enolate Cyclization - Journal of the American Chemical Society (ACS Publications)

A palladium-catalyzed chelation-assisted C−H activation of alkyl aryl ketones and their reaction with aryl iodides to afford ortho-arylated products is described. For sec-alkyl aryl ketones, the catalytic reaction proceeds further to give 10,10-dialkylphenanthrone derivatives. A possible reaction mechanism involving directed dual C−H bond activation and enolate cyclization for the formation of 10,10-dialkylphenanthrone derivatives is proposed.